Make faster, better drug development decisions
Therapeutics which exploit the DNA damage response (DDR) and optimize synthetic lethality have proved to be effective anti-cancer treatments. With four FDA-approved PARP inhibitors, the field is expanding rapidly both within and beyond PARP.
Keep track of this evolving landscape, including novel approaches and combination strategies, using Beacon DDR. In one easy-to-use database, Beacon DDR allows you to rapidly find the information you need and focus time on advancing your research.
Beacon DDR
How the most complete clinical trial and drug landscape for DDR can help you
What we cover
Beacon DNA Damage Response (DDR) covers trial and drug records for clinical, preclinical, approved and discontinued therapeutics targeting key points in DNA damage response pathways.
This module identifies drugs utilizing the concept of synthetic lethality, and covers DDR repair pathway components, including:
- Damage Sensors
- Signalling/Mediator Proteins
- Effector Proteins
- Cell Cycle Checkpoints
- DNA Metabolism when in relation to repair and recombination
Several key therapeutic targets in the DDR landscape included in this module are:
- PARP
- ATM
- ATR
- CHK1/2
- WEE1
- DNA-PK
- POLQ
- WRN
- PARG
New data expansion: Deals and Companies. Gain unparalleled access to in-depth company profiles and the latest commercial deals. Monitor your competitors and opportunities as well as benchmark deals and evaluate potential partners. Learn more about Deals and Companies data by downloading the factsheet.
How Beacon helps
Here are some examples of how Beacon DDR can accelerate your research programs:
- Search for DDR drugs across all stages of development so you can accurately benchmark your strategies against other preclinical and clinical drugs, and investigate the novel approaches used by competitors.
- Drastically reduce time spent looking through publications and conference abstracts for clinical trial results by relying on our comprehensive collection of data which can be searched by disease, combination treatments and much more.
- Stay on top of emerging trends and new players in the field with real-time updates and alerts, as well as in-depth monthly reports curated by our expert analyst team.
How Beacon DDR works
Search the trial and drug landscape by target, repair pathway and mechanism of action alongside 15 other search criteria including disease, line of therapy, biomarker, sponsor, plus more, to instantly extract the data points you need to conduct more complex analyses.
Our unique Milestones filter and visualization highlights past, present, and future drug development milestones including drug and trial readouts, asset history, and regulatory announcements. This enhancement provides an accurate, timely and exhaustive single-drug timeline allowing you to benchmark progress in the DDR space.
How we target the data for DNA damage repair therapeutics
We house all publicly available sources of data updated with 24 – 48 hours of publication proactively. Our sources cover (but are not limited to):
- Clinical trials registries
- Scientific journals and publications
- Company reports and presentations
- Press releases
- Conference reports and abstracts
- Government and regulatory organizations
- Newspapers and other media
- Patents
Related content
DDRi and ADC Combination Therapies Infographic
The 2024 DDR H1 Landscape Review
Investment Trends in Early-Stage Biopharma: A Beacon Data Perspective
What our customers say
Beacon is a great database that people should pay attention to. It's much better than many of the more generic databases that try to capture all data about everything
Director
Top Biotech Company
Our DDR Expert
Kieran Pinto is the lead research analyst for Beacon DDR
Sign up to his weekly newsletter to uncover the latest insights into the DDR landscape using data from Beacon.
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Any questions? Contact us
To learn more about how we can tailor Beacon DDR to help you, get in touch with our sales team
About Beacon
We are a clinical trial and pipeline database solution, designed in partnership with pharmaceutical professionals. We track targeted therapies to provide accurate, in-depth and real-time information in the rapidly evolving landscape of drug development.
