About the Infographic

As the DDR space seeks to find efficacious combinations whilst minimising toxicity to patients, combination therapies are becoming a key topic of discussion. This infographic looks at current combination therapies being evaluated in the clinic by target, disease indication and more, with a particular focus on ATR inhibitors and DDRi’s in combination with ADC’s.

Infographic highlights include:

    • An overview of the DDR combination therapy landscape
    • A look at ATRi’s and ICM’S
    • A focus on the emerging combination strategy of DDRi’s and ADC’S
    • A summary of the current landscape and key learnings

The Combination Therapies Infographic

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Beacon DDR

How the most complete DDR database can help you

What we cover

Beacon DNA Damage Response (DDR) covers trial and drug records for clinical, preclinical, approved and discontinued therapeutics targeting key points in DNA damage response pathways.  

This module identifies drugs utilizing the concept of synthetic lethality, and covers DDR repair pathway components, including: 

  • Damage Sensors  
  • Signalling/Mediator Proteins  
  • Effector Proteins  
  • Cell Cycle Checkpoints  
  • DNA Metabolism when in relation to repair and recombination  

Several key therapeutic targets in the DDR landscape included in this module are: 

  • PARP  
  • ATM  
  • ATR  
  • CHK1/2  
  • WEE1  
  • DNA-PK 
  • POLQ
  • WRN
  • PARG

How Beacon DDR works

Search the trial and drug landscape by target, repair pathway and mechanism of action alongside 15 other search criteria including disease, line of therapy, biomarker, sponsor etc. to instantly extract the data points you need to conduct more complex analysis.