About the Infographic
As the DDR space seeks to find efficacious combinations whilst minimising toxicity to patients, combination therapies are becoming a key topic of discussion. This infographic looks at current combination therapies being evaluated in the clinic by target, disease indication and more, with a particular focus on ATR inhibitors and DDRi’s in combination with ADC’s.
Infographic highlights include:
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- An overview of the DDR combination therapy landscape
- A look at ATRi’s and ICM’S
- A focus on the emerging combination strategy of DDRi’s and ADC’S
- A summary of the current landscape and key learnings
Find out more
Beacon is the essential decision-support tool for developers of complex therapeutics. Our market-defining, proprietary ontologies, combined with the most accurate and comprehensive life sciences data, provide our customers with unparalleled visibility of the drug and trial landscape.
With Beacon, you can make drug development decisions with confidence. This is why 23 of the world’s top 25 drug developers trust us.
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Beacon DDR
How the most complete DDR database can help you
What we cover
Beacon DNA Damage Response (DDR) covers trial and drug records for clinical, preclinical, approved and discontinued therapeutics targeting key points in DNA damage response pathways.
This module identifies drugs utilizing the concept of synthetic lethality, and covers DDR repair pathway components, including:
- Damage Sensors
- Signalling/Mediator Proteins
- Effector Proteins
- Cell Cycle Checkpoints
- DNA Metabolism when in relation to repair and recombination
Several key therapeutic targets in the DDR landscape included in this module are:
- PARP
- ATM
- ATR
- CHK1/2
- WEE1
- DNA-PK
- POLQ
- WRN
- PARG
How Beacon DDR works
Search the trial and drug landscape by target, repair pathway and mechanism of action alongside 15 other search criteria including disease, line of therapy, biomarker, sponsor etc. to instantly extract the data points you need to conduct more complex analysis.
