Beacon TPD Database

Advanced Filtering

How it Helps

Data Coverage

Drug Modalities

Who is it For?

Beacon TPD Database Summary

Unrivalled comprehensive & accurate preclinical and clinical TPD drug, trial and commercial data.
Access to 1,900+ Drugs, 800+ Trials, 3,200+ Companies, and 900+ Deals in the TPD space
Market leading ontologies, enabling precise navigation of the TPD drug development landscape
Manually curated by TPD scientists, with data updated daily
Your one stop shop for TPD intelligence data

Why Beacon TPD Database?

Advanced Search Filtering

Drill down into Beacon’s TPD drug and trial data with a unique selection of >30 search filters. Segment the TPD drug and trial landscape to identify the data that matters most to you. Our filters include:

Drug Target

Drug Modality

Disease Indication

Ligand (Effector)

Ligand (Target)

Linker

Drug Status

Drug & Trial Milestones

Trial Phase & Location

How Beacon TPD Database Can Help You?

How do I design an optimized & differentiated degrader or molecular glue?

Give your TPD molecular design gives the best chance of success for a given targe & modality with unique TPD searching ontologies based on therapeutic modality (PROTACs, LYTACs, Molecular Glues etc.), ligand (effector), ligase/ effector, ligand (target) & binding mode, all tagged to market leading granularity levels by a team of TPD analysts.

Access curated technology data to benchmark against including SMILES codes, and structures, binding affinity, DC50/DC90 & Dmax values.

How do I ensure my preclinical TPD data is robust enough to accelerate into the clinic?

Benchmark your preclinical TPD research with confidence by accessing more preclinical data than anywhere else across in vitro, PK, efficacy & toxicity, readouts, allowing you to benchmark experimental designs and animal models leveraged & understand the latest data emerging from conferences & all other public sources

How can I optimise the DMPK profile of my heterobivalent degrader?

Access a wealth of clinical & preclinical DMPK data in one place to benchmark against for novel technologies emerging in pipelines, with curated data points including:

Oral bioavailability
DC50 (concentration at which the target protein is degraded by 50%)
Dmax (maximum percentage of target protein degraded)
Observed degradation – in the absence of a DC50 value
Permeability
Solubility
Tumour/cell line expression level
In vivo activity

How can I design a TPD trial that gives the best chance of success?

Follow preclinical readouts through to the latest degrader clinical readouts in one place, to understand how PK profiles can be predictors of clinical success and how dose escalation strategies have been successful or failed in a novel clinical landscape to inform your own patient selection & clinical strategy

How can I find the right partners in a competitive TPD market?

Optimize your TPD partnership strategy by identifying new prospect companies or competitors as soon as they enter the field, taking advantage of Beacon’s unique approach to capturing early-stage companies and curated insights on deals & pipelines all in one place

How do I differentiate my pipeline & raise the vital capital to take our protein degrader to the next phase?

Bulletproof your TPD investment strategy by confidently communicating your position in the TPD market to investors, with well benchmarked science, allowing you to stand out in a competitive market using robust data from Beacon.

Beacon helps developers stand out by providing comprehensive insights into targets, diseases, and vaccine design & enhances your ability to attract investors and secure the capital needed to take your TPD drug to the next phase.

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Beacon TPD Database: The Numbers

1,900+

TPD Drugs

3,300+

TPD Trials

3,200+

TPD Companies

1,300+

TPD Deals

Beacon TPD Database: Key Data Segments

Drug Data

Revolutionize your landscape searching for TPD drug development

Utilize >20 search filters to find programs based on disease indication, drug modality, target and effector ligand, linker and many more.

Trial Data

Optimize your TPD clinical trial design searching capabilities.

Seamlessly benchmark clinical trial results and search the TPD trial landscape based on drug technologies, combination trials, trial locations, trial phase, disease indication and more.

Milestones

A unique TPD drug development milestone filter and visualization tool.

Track past, present, and future TPD drug development milestones, including drug and trial readouts, asset history, and regulatory announcements.

Company Data

Your centralized location for TPD company intelligence

Identify competitors and business development opportunities, using unique company filters including, company type, HQ locations, operating status & latest funding round, and technologies / diseases targeted in their pipeline.

Deal Data

De-risk your TPD partnership & fundraising projects

Search TPD deals using custom search filters based on drug technologies involved, deal value & upfront payments, deal types to filter M&As, financing & partnership / licensing deals, geographic market, funding type, and many more.

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Beacon TPD Database: Drug Modalities

Analyze 3,200 + drugs (preclinical and clinical) and 1,300 + clinical trials (from early to late stage).

Beacon TPD covers heterobifunctional molecules, or any small molecule, that can bring two moieties together to induce protein-protein proximity, which effects target protein abundance/function to cause a therapeutic effect.

Drug Modalities include:
Bivalent and Monovalent Degraders
Induced Proximity Assets
Proteasome Inhibitors
DUB Inhibitors
E1/E2/E3/Modulators
Other Comparable Modalities

Beacon TPD also includes a host of preclinical data including, cell line and animal model experimental data.

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Who is Beacon TPD Database For?

Beacon TPD is a manually curated database of comprehensive, high quality, and accurate, preclinical and clinical drug, trial and commercial data, offering unrivalled insight into the TPD drug development landscape.