Disease Trends in the Oligonucleotide Space

Beacon RNA’s newest digest reveals how the oligonucleotide drug development landscape is evolving, using insights sourced directly from the comprehensive Beacon RNA database. As the focus expands beyond rare genetic disorders toward more prevalent conditions such as cardiovascular and metabolic diseases, this report highlights the key trends shaping both scientific direction and investment strategies.

Disease Trends in the Oligonucleotide Space

Using data derived from Beacon as of April 2025, the slides cover the following:

  • Disease trend insights across over 2,100 therapies, with deep dives into the rise of siRNA and ASO modalities.
  • Pipeline growth snapshots, including 60+ new siRNA programs since January 2025 and a surge in early-stage oligonucleotide assets.
  • Clinical progress tracking, revealing trial activity by disease type and phase, and showcasing cardiovascular drugs with standout efficacy data.

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