What the Data Tells us
The data from ASGCT 2026 reinforces a clear industry challenge: while innovation continues to expand rapidly, translating early-stage breakthroughs into approved therapies remains limited.
A significant proportion of assets are still in preclinical development, highlighting ongoing challenges in delivery, safety, and manufacturing. At the same time, the increasing overlap between modalities signals a shift toward more integrated, platform-driven strategies across the advanced therapy landscape.
Gene therapy continues to lead in activity, but RNA and cell therapies are driving innovation at the edges, particularly in CNS and autoimmune indications where new delivery approaches are unlocking previously inaccessible targets.
Download the Report to:
- Understand pipeline dynamics at scale. Explore hundreds of advanced therapy assets across gene therapy, cell therapy, and RNA, with clear visibility into development stage progression and approval bottlenecks.
- Identify where innovation is accelerating. See how cross-modality approaches, including hybrid gene, cell, and RNA therapies, are shaping next-generation development strategies.
- Track clinical vs preclinical momentum. Gain insight into why 74% of activity remains preclinical, and what this means for timelines, risk, and investment decisions.
- Spot high-value therapeutic and disease areas. Analyze trends across oncology, CNS, autoimmune, and rare diseases to pinpoint emerging opportunities.
- Evaluate delivery and platform innovation. Understand the continued dominance of AAV vectors alongside the rise of LNPs and next-generation delivery technologies.
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