Co-Stimulatory Bispecifics: Strategic Insights into T-Cell Activation

A new class of bispecific antibodies is redefining how immune responses are activated in oncology.

As the field moves beyond first-generation CD3-targeting approaches, co-stimulatory strategies are gaining traction for their potential to deliver more precise, controlled, and effective T-cell activation, offering new opportunities to differentiate pipelines and improve therapeutic outcomes.

Download the report to gain a clear, data-driven view of this rapidly evolving landscape and the strategies shaping its future.

Co-stimulatory bispecific antibodies are gaining momentum, with activity ramping up across key targets such as 4-1BB and CD28, alongside a broader set of emerging receptors shaping the next phase of development.

As the field evolves, key questions remain around how to translate early promise into clinical success, balance efficacy with safety, and differentiate in this competitive field.

Built using data from Beacon Bispecific, this report provides a clear, structured view of where the space stands today and where it’s heading next.

Key questions answered:

  • Which co-stimulatory targets are driving momentum and how is the landscape evolving?
  • Where is clinical activity accelerating, and which programs are setting the pace?
  • How is the competitive and deal-making landscape shaping development strategies?
  • What does the next wave of innovation look like, including dual co-stimulation and combination approaches?
  • Which promising assets should be on your radar?
Co-Stimulatory Bispecifics Report

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What is Beacon Bispecific?
  • The Most Comprehensive Way to Search the Bispecific Drug Development Landscape: Unique search ontologies based on Bispecific drug and trial characteristics
  • Market Leading Approach to Bispecific Preclinical & Clinical Data Curation: Manual curation of key Bispecific research and development data points Bispecific research scientists
  • Seamlessly Integrate Commercial & Scientific Data all in One Place: Search Bispecific company and deal data based on their pipeline and technologies.
  • Unrivalled Granularity in Reports & Analysis: Our search ontology and technology indexing enable comprehensive analysis not seen elsewhere.
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What is Beacon?

Beacon is a world leading data analysis tool for preclinical and clinical trial information. With unrivalled granularity of search function, data quality, and exhaustiveness, Beacon provides timely information and gives you confidence to progress your targeted drug therapies to patients.

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