Recent advances in ADC linker technology have enhanced ADC stability in the bloodstream, reduced payload hydrophobicity, and enabled higher DAR and multiple payload constructs. A consequence of these advancements is significantly increased complexity of the linker and linker-payload structures and associated synthetic chemistry challenges. This webinar will highlight the structural features of the newest classes of linkers and address some of the challenges in the synthesis and purification of payload-linker constructs for the preparation of clinical ADCs so you can understand how best to utilize these advances in your ADC constructs.
Key Highlights:
- An introduction to ADC linkers, including their impact on ADC, stability, aggregation and targeted release.
- Examples of some new PEGylated, polyhydroxylated and branched linker structures.
- Discussion of synthetic strategies to maximize convergence and to minimize the number of highly potent steps.
- Purification strategies for very hydrophilic compounds to minimize reliance on preparative HPLC.
Why Attend?
- Gain an understanding of the evolution of ADC linkers from simple disulfides and dipeptides to complex, PEGylated, polyhydroxylated and/or branched structures.
- Learn about the challenges in developing synthetic strategies for GMP manufacture of these complex linkers.
Join us for an informative session that will provide fascinating insights into how ADC linker technologies have grown and matured along with the space, and how you can harness the latest developments to supercharge your ADC constructs. Register now to secure your spot!
Webinar Leaders
Dr. William Sanders
Global Vice President of Chemical Development Operations at Veranova
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