The RNA Therapeutics Landscape in 2025: Current Dynamics and Future Direction
The 2025 RNA Landscape Review provides a clear, data-driven snapshot of how the RNA therapeutics field is evolving, integrating insights across drug development, clinical progress, regulatory activity, and commercial momentum.
Covering both established and emerging RNA modalities, including mRNA, siRNA, antisense oligonucleotides, and precision base-editing technologies. The review assesses pipeline expansion, competitive intensity, and areas of emerging differentiation.
Part 1 focuses on the RNA drug landscape, examining how assets are distributed across modalities, development stages, and therapeutic areas, alongside recent approvals and pipeline growth, to highlight where innovation is concentrating and which drug strategies are shaping the future RNA pipeline.
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Report Contents
The Drug Landscape
Explore an RNA pipeline of 6,000+ assets, shaped by rapid mRNA expansion and growing momentum behind RNA and DNA base-editing approaches.
The Trial Landscape
Track over 2,700 RNA trials, as 2025 additions rise 23% YoY and mRNA activity rebounds following recent declines.
The Commercial Landscape
Uncover 3,100+ RNA companies, as Asia and North America drive the fastest growth in global RNA development.
The Future of RNA Therapeutics
Examine how strong developer confidence in 2025 drove 22 new RNA INN additions, including a rise in gRNA-mediated gene-editing assets despite fewer trial initiations.
Regulatory Announcements
Review the regulatory momentum of 2025, with 169 INDs granted, marking a 41% increase year-on-year and signalling accelerating early-stage RNA therapeutic development.
Previous RNA Landscape Reviews
RNA 2024 H1 Landscape Review
An analysis of the RNA landscape in H1 of 2024
RNA 2024 Landscape Review
Uncover the key 2024 RNA breakthroughs and stay ahead in the rapidly evolving RNA landscape.
H1 2025 Landscape Review
Explore the defining RNA breakthroughs of H1 2025 and understand what’s shaping the RNA landscape next.
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Learn More About RNA
- The Most Comprehensive Way to Search the RNA Drug Development Landscape: Unique search ontologies based on RNA drug and trial characteristics
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- Seamlessly Integrate Commercial & Scientific Data all in One Place: Search RNA company and deal data based on their pipeline and technologies.
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